FinnGen EA3 study for Women’s health in Female infertility and Polycystic ovary syndrome PCOS


PCOS is the most common endocrine disorder in women, affecting 10-18% of fertile women. There seems to be several different phenotypes with different health outcomes. We aim to study phenotypic differences by using clinical measures. 1) Serum AMH and gonadotropins to identify “reproductive phenotype” 2) serum testosterone, FAI and hair growth information (hirsutism) for hyperandrogenic phenotype 3) metabolic markers to identify “metabolic phenotype”. Addition of the presented parameters to FinnGen would greatly improve quality and impact of PCOS GWAS studies.